According to some Byzantine local traditions, “Let my prayer arise” is to be sung in the fifth tone at all Wednesday and Friday Presanctified liturgies, but in the sixth tone in the first week, during Great Week, and anytime the Presanctified is served for a ranking commemoration. This harmonization is loosely based on the tone 6 version in the Greek chantbooks. The verses would be intoned either by the priest or by a chanter, with the full choir responding with the refrain.
Daniel E. Johnson
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Johnson, Daniel